Calcium-channel blockers and cognitive function in elderly people: results from the Canadian Study of Health and Aging

Table 4: Unadjusted and adjusted ORs* for cognitive decline† associated with use of selected antihypertensive drugs by the 205 subjects Characteristic     Unadjusted OR      (and 95% CI)      Adjusted OR      (and 95% CI) ß-Blocker (reference group) 1.00   1.00   ACE inhibitor 1.54   (0.50–4.74) 1.36   (0.41–4.55) Diuretic or other antihypertensive 1.49   (0.55–4.00) 1.45   (0.51–4.14) Nifedipine 1.51   (0.44–5.24) 1.94   (0.52–7.27) Diltiazem or verapamil 2.60   (0.94–7.22) 3.72   (1.22–11.36) *Obtained from multivariate logistic regression model, adjusted for age, sex, use of other drugs, history of stroke or diabetes, cardiac symptoms and diastolic blood pressure. †Defined as a decrease in 3MS score of 10 points or more.

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