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CMAJ
CMAJ - February 8, 2000JAMC - le 8 février 2000

Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report

Fig. 2: Autoradiograms of polyethyleneimine-cellulose thin layer chromatography maps of 32P-labelled digests of DNA (autoradiography performed with Kodak Biomax MR film for 3 hours at ­70°C). Left: DNA from HepG2 cells treated with 400 µmol/L 1´-hydroxysafrole for 24 hours. One safrole-DNA adduct visualized as a black spot can be clearly seen in the bottoom left corner of this autoradiogram. Right: DNA from liver biopsy specimen. A safrole-DNA adduct can be seen at the bottom left corner of this autoradiogram.

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